Halfway by way of his career, Cees Dekker reinvented himself. Soon after many years of hardcore physics, he shifted his concentration to ‘nanobiology’ on the transform on the millennium. A time period he coined himself, like a make any difference of reality.
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Dynamics of initiation, termination and reinitiation of DNA translocation by the motor protein EcoR124I
Our function was swiftly followed up by Some others, most notably by Phaedon Avouris and colleagues at IBM, who in Oct 1998 released their conclusions on transistors comprised of one- and multi-walled carbon nanotubes in Used Physics Letters.
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Electrical transportation in monolayers of phthalocyanine molecular wires and AFM imaging of an individual wire bridging two electrodes
What distinguishes biology from chemistry is the fact that these parts with each other make up a dwelling method. The trick of mentioned everyday living, I believe, lies during the interactions, the interplay of All those molecules. The big concern concerning the origin of life continues to be unanswered. How did we at any time evolve from easy molecules in the extremely intricate systems we see right now? We do not know. I want to work on These types of significant, open queries.’
Nanopores signify an elegant and flexible Instrument to measure single molecules. We study novel detection modes with strong-state nanopores as well as various approaches to measure proteins with nanopores. Projects encompass the following:
2003, shown the 1st biosensors designed away from a carbon nanotube; settled the structure and system of DNA repair service proteins; and discovery of a whole new strategy for fabricating sound-state nanopores for DNA translocation
Dekker commenced his analysis on one carbon nanotubes in 1993 when he put in place a brand new line of research to review electrical transport as a result of solitary organic molecules involving nanoelectrodes. In 1996 a breakthrough was realized with carbon nanotubes. This was obtained in the collaboration Using the team of Nobel laureate Richard Smalley. STM and nanolithography strategies were accustomed to demonstrate that these nanotubes are quantum wires at The one-molecule degree, with superb Bodily Attributes.
Example (four) of bending configurations in 3D simulations of DNA rods on nanopores. A part of the membrane is proven in grey, the rim of your pore is highlighted in purple, as well as a 3D rendering in the motion with the DNA rod is shown.
2001, discovery of single-electron transistors at room temperature depending on nanotubes; realization of 1st logic circuits cees dekker with carbon nanotube units; and discovery on the molecular framework of DNA mend enzymes with AFM
Allow’s very first seem back again at this time when you decided to shift your focus from superconductivity and nanotubes to biology at the end of the 1990s.
Supercoiling-dependent DNA binding: quantitative modeling and programs to bulk and one-molecule experiments